Premium
Multilocus Binding Increases the Relaxivity of Protein‐Bound MRI Contrast Agents
Author(s) -
Zhang Zhaoda,
Greenfield Matthew T.,
Spiller Marga,
McMurry Thomas J.,
Lauffer Randall B.,
Caravan Peter
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502245
Subject(s) - flexibility (engineering) , contrast (vision) , chemistry , computer science , computational biology , biophysics , biology , artificial intelligence , mathematics , statistics
Spinning around : The sensitivity of MRI contrast agents can be increased through multilocus binding. This restricts the internal motion and therefore increases the relaxivity of a bound protein multimer (see picture; A) relative to a single binding group (B), whose flexibility and internal motion limits the relaxivity gain. Protein‐targeting groups (TG) can be used to anchor the multimer.