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Highly Efficient Reagents for Br/Mg Exchange
Author(s) -
Krasovskiy Arkady,
Straub Bernd F.,
Knochel Paul
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502220
Subject(s) - aryl , reagent , reactivity (psychology) , magnesium , chemistry , combinatorial chemistry , content (measure theory) , quantum chemical , organic chemistry , computational chemistry , molecule , mathematics , medicine , alkyl , alternative medicine , pathology , mathematical analysis
The conversion of electron‐rich aryl bromides into the corresponding Grignard compounds proceeds within 2 h at 25 °C in the presence of 0.55 equivalents of the new reagent s Bu 2 Mg⋅LiCl. The high reactivity of magnesiates is rationalized by quantum chemical model calculations, and selected examples illustrate the benefits of aryl magnesium compounds for organic syntheses.