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Hydrogel Stamping of Arrays of Supported Lipid Bilayers with Various Lipid Compositions for the Screening of Drug–Membrane and Protein–Membrane Interactions
Author(s) -
Majd Sheereen,
Mayer Michael
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502189
Subject(s) - stamping , membrane , agarose , chemistry , lipid bilayer , membrane protein , nanotechnology , computer science , computational biology , biochemistry , materials science , biology , metallurgy
Stamping on fat : Agarose gel stamps were used to create ≥100 membrane arrays (see picture) by using only picomolar amounts of lipids. This constitutes a rapid and straightforward method for the fabrication of functional membrane arrays with a variety of lipid compositions which can be used for screening assays, for example, for drug–membrane interactions.