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Selective Sensing of Zinc Ions with a PARACEST Contrast Agent
Author(s) -
Trokowski Robert,
Ren Jimin,
Kálmán Ferenc Krisztián,
Sherry A. Dean
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502173
Subject(s) - europium , zinc , paramagnetism , ion , chemistry , saturation (graph theory) , hydroxide , contrast (vision) , ion exchange , nuclear magnetic resonance , computer science , inorganic chemistry , physics , organic chemistry , artificial intelligence , condensed matter physics , mathematics , combinatorics
A europium complex capable of selectively binding zinc (see picture) has been developed as a new paramagnetic chemical exchange saturation transfer (PARACEST) imaging agent for use in magnetic resonance imaging (MRI). A hydroxide group on the bound Zn ion increases the rate of water exchange on the Eu ion.