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One‐Pot Reaction Cascades Using Star Polymers with Core‐Confined Catalysts
Author(s) -
Helms Brett,
Guillaudeu Steven J.,
Xie Yu,
McMurdo Meredith,
Hawker Craig J.,
Fréchet Jean M. J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502095
Subject(s) - catalysis , nucleophile , amine gas treating , homogeneous , chemistry , steric effects , polymer , star (game theory) , polymer chemistry , organic chemistry , combinatorial chemistry , physics , thermodynamics , astrophysics
My stars! Star polymers that contain otherwise incompatible acid or base catalysts, such as para ‐toluenesulfonic acid or 4‐(dialkylamino)pyridines moieties, at their sterically restricted cores (see scheme) are readily prepared. Homogeneous catalysis using these star polymers can perform reaction cascades in the same pot and is demonstrated with an acid‐catalyzed deprotection and the nucleophilic amine‐catalyzed Baylis–Hillman reaction.