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Stereoselective Palladium‐Catalyzed Four‐Component Cascade Synthesis of Pyrrolidinyl‐, Pyrazolidinyl‐, and Isoxazolidinyl Isoquinolines
Author(s) -
Dondas H. Ali,
Fishwick Colin W. G.,
Gai Xinjie,
Grigg Ronald,
Kilner Colin,
Dumrongchai Nuethip,
Kongkathip Boonsong,
Kongkathip Ngampong,
Polysuk Chatchwan,
Sridharan Visuvanathar
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502066
Subject(s) - stereocenter , allene , component (thermodynamics) , cycloaddition , stereoselectivity , cascade , chemistry , palladium , catalysis , combinatorial chemistry , stereochemistry , computer science , organic chemistry , enantioselective synthesis , physics , chromatography , thermodynamics
Two paths diverge : Four‐component cascades that involve the cycloaddition of azomethine ylides, azomethine imines, or nitrones generated in situ, coupled with allene incorporation, give rise to five new bonds, two rings, and two to four stereocenters through two possible pathways (see picture for an example).