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Site‐Selective Protein Immobilization by Staudinger Ligation
Author(s) -
Watzke Anja,
Köhn Maja,
GutierrezRodriguez Marta,
Wacker Ron,
Schröder Hendrik,
Breinbauer Rolf,
Kuhlmann Jürgen,
Alexandrov Kirill,
Niemeyer Christof M.,
Goody Roger S.,
Waldmann Herbert
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502057
Subject(s) - ligation , azide , chemistry , computational biology , combinatorial chemistry , computer science , nanotechnology , microbiology and biotechnology , materials science , biology , organic chemistry
A sticky situation : A site‐specific immobilization of proteins onto a glass surface may allow the creation of protein microarrays. This approach relies on the Staudinger ligation between azide‐modified proteins and a phosphane‐functionalized glass surface.