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Chemo‐, Regio‐, and Stereoselective Cobalt‐Mediated [2+2+2] Cycloaddition of Alkynyl Boronates to Alkenes: 1,3‐ and 1,4‐Diboryl‐1,3‐cyclohexadienes
Author(s) -
Gandon Vincent,
Leboeuf David,
Amslinger Sabine,
Vollhardt K. Peter C.,
Malacria Max,
Aubert Corinne
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502038
Subject(s) - pinacol , stereoselectivity , chemistry , cycloaddition , cobalt , combinatorial chemistry , oxidative phosphorylation , organic chemistry , stereochemistry , medicinal chemistry , catalysis , biochemistry
Diborylated compounds are obtained by means of CpCo‐mediated cocyclization of alkynyl(pinacol)boronic esters to alkenes followed by oxidative demetalation (see scheme). This strategy for the rapid and efficient construction of highly functionalized 1,3‐cyclohexadienes and arenes is compatible with various substrates.