Highly Enantioselective Pd‐Catalyzed Allylic Alkylations of Acyclic Ketones | Zendy

Yan XiaoXia | Zendy; Liang ChunGen | Zendy; Zhang Yan | Zendy; Hong Wei | Zendy; Cao BoXun | Zendy; Dai LiXin | Zendy; Hou XueLong | Zendy

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Highly Enantioselective Pd‐Catalyzed Allylic Alkylations of Acyclic Ketones

Author(s) -

Yan XiaoXia,

Liang ChunGen,

Zhang Yan,

Hong Wei,

Cao BoXun,

Dai LiXin,

Hou XueLong

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200502020

Subject(s) - enantioselective synthesis , allylic rearrangement , catalysis , tsuji–trost reaction , chemistry , ligand (biochemistry) , simple (philosophy) , ketone , combinatorial chemistry , organic chemistry , stereochemistry , philosophy , biochemistry , receptor , epistemology

Pocket the difference : Highly enantioselective allylic alkylation of simple acyclic ketones is carried out by using a Pd catalyst with a “chiral pocket” ligand 1 (see scheme). The addition of a Lewis acid such as AgBr and the selection of one enolate form over another dramatically affect the enantioselectivity of the reaction.

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