Premium
Highly Enantioselective Pd‐Catalyzed Allylic Alkylations of Acyclic Ketones
Author(s) -
Yan XiaoXia,
Liang ChunGen,
Zhang Yan,
Hong Wei,
Cao BoXun,
Dai LiXin,
Hou XueLong
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502020
Subject(s) - enantioselective synthesis , allylic rearrangement , catalysis , tsuji–trost reaction , chemistry , ligand (biochemistry) , simple (philosophy) , ketone , combinatorial chemistry , organic chemistry , stereochemistry , philosophy , biochemistry , receptor , epistemology
Pocket the difference : Highly enantioselective allylic alkylation of simple acyclic ketones is carried out by using a Pd catalyst with a “chiral pocket” ligand 1 (see scheme). The addition of a Lewis acid such as AgBr and the selection of one enolate form over another dramatically affect the enantioselectivity of the reaction.