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General Catalysts for the Suzuki–Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water
Author(s) -
Anderson Kevin W.,
Buchwald Stephen L.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502017
Subject(s) - sonogashira coupling , aryl , phosphine , catalysis , chemistry , substrate (aquarium) , combinatorial chemistry , amphiphile , coupling (piping) , palladium , organic chemistry , materials science , copolymer , polymer , metallurgy , alkyl , oceanography , geology
Amphiphilic phosphine ligands (see structures; Cy=cyclohexyl) were prepared and utilized in palladium‐catalyzed Suzuki–Miyaura and Sonogashira coupling reactions in water or water/organic biphasic solvents, providing excellent yields of functionalized biaryls and aryl alkynes, respectively.