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Solution‐Phase Mixture Synthesis with Double‐Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins
Author(s) -
Wilcox Craig S.,
Gudipati Venugopal,
Lu Hejun,
Turkyilmaz Serhan,
Curran Dennis P.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501989
Subject(s) - separation (statistics) , phase (matter) , chromatography , chromatographic separation , separation method , chemistry , combinatorial chemistry , scheme (mathematics) , computer science , organic chemistry , high performance liquid chromatography , mathematics , machine learning , mathematical analysis
Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double‐separation tagging procedure. A strategy for solution‐phase stereoisomer synthesis based on double‐separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH 2 CH 2 ) n OCH 3 ) tags.