Solution‐Phase Mixture Synthesis with Double‐Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins | Zendy

Wilcox Craig S. | Zendy; Gudipati Venugopal | Zendy; Lu Hejun | Zendy; Turkyilmaz Serhan | Zendy; Curran Dennis P. | Zendy

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Solution‐Phase Mixture Synthesis with Double‐Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins

Author(s) -

Wilcox Craig S.,

Gudipati Venugopal,

Lu Hejun,

Turkyilmaz Serhan,

Curran Dennis P.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501989

Subject(s) - separation (statistics) , phase (matter) , chromatography , chromatographic separation , separation method , chemistry , combinatorial chemistry , scheme (mathematics) , computer science , organic chemistry , high performance liquid chromatography , mathematics , machine learning , mathematical analysis

Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double‐separation tagging procedure. A strategy for solution‐phase stereoisomer synthesis based on double‐separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH 2 CH 2 ) n OCH 3 ) tags.

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