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Cooperative Binding of p53 to DNA: Regulation by Protein–Protein Interactions through a Double Salt Bridge
Author(s) -
Dehner Alexander,
Klein Christian,
Hansen Silke,
Müller Lin,
Buchner Johannes,
Schwaiger Manfred,
Kessler Horst
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501887
Subject(s) - transcription factor , suppressor , dna , genetics , dna binding protein , mutation , biology , transcription (linguistics) , li–fraumeni syndrome , dna damage , cancer research , chemistry , microbiology and biotechnology , cancer , germline mutation , gene , linguistics , philosophy
Mutations in the transcription factor p53 enhance one's predisposition to cancer. Mutational studies show that double salt bridges are key elements for the dimerization of p53, its cooperative binding to DNA, and thus its proper function as a tumor suppressor (see picture). This might explain certain germ‐line mutations found in patients with Li–Fraumeni syndrome.