Charge Interactions Do the Job: A Combined Statistical and Combinatorial Approach to Finding Artificial Receptors for Binding Tetrapeptides in Water | Zendy

Schmuck Carsten | Zendy; Heil Martin | Zendy; Scheiber Josef | Zendy; Baumann Knut | Zendy

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Charge Interactions Do the Job: A Combined Statistical and Combinatorial Approach to Finding Artificial Receptors for Binding Tetrapeptides in Water

Author(s) -

Schmuck Carsten,

Heil Martin,

Scheiber Josef,

Baumann Knut

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501812

Subject(s) - quantitative structure–activity relationship , receptor , statistical analysis , chemistry , scheme (mathematics) , computational biology , computer science , artificial intelligence , biological system , combinatorial chemistry , mathematics , stereochemistry , biology , biochemistry , statistics , mathematical analysis

Statistical QSAR analysis (QSAR=quantitative structure–activity relationship) was applied to quantitative experimental screening data of a small, but focused, combinatorial library to identify potent receptors ( 1 , see scheme). Analysis showed that no receptors with better efficiency would be expected, even if a 15‐times larger library was used.

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