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Synthesis, Anion‐Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues
Author(s) -
Sessler Jonathan L.,
Eller Leah R.,
Cho WonSeob,
Nicolaou Sergios,
Aguilar Apolonio,
Lee Jeong Tae,
Lynch Vincent M.,
Magda Darren J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501740
Subject(s) - prodigiosin , in vitro , chemistry , symporter , combinatorial chemistry , chloride , computational biology , biochemistry , stereochemistry , biology , organic chemistry , transporter , escherichia coli , serratia marcescens , gene
Pro and anti : Recognition of chloride ion and through‐membrane H + /Cl − ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally occurring pigment (see picture).