Premium
Concise Syntheses of Meridianins by Carbonylative Alkynylation and a Four‐Component Pyrimidine Synthesis
Author(s) -
Karpov Alexei S.,
Merkul Eugen,
Rominger Frank,
Müller Thomas J. J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501703
Subject(s) - alkynylation , component (thermodynamics) , aryl , carbon monoxide , chemistry , carbonylation , pyrimidine , combinatorial chemistry , organic chemistry , catalysis , stereochemistry , physics , alkyl , thermodynamics
In one go : (Hetero)aryl iodides, alkynes, carbon monoxide, and amidines can be assembled in a consecutive four‐component reaction to give pyrimidines by a sequence of carbonylative alkynylation and cyclocondensation. Carbonylative alkynylation also is the key step in the two‐step syntheses of meridianins and meridianin derivatives.