A Method for Trapping Intermediates of Polyketide Biosynthesis with a Nonhydrolyzable Malonyl‐Coenzyme A Analogue | Zendy

Spiteller Dieter | Zendy; Waterman Claire L. | Zendy; Spencer Jonathan B. | Zendy

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A Method for Trapping Intermediates of Polyketide Biosynthesis with a Nonhydrolyzable Malonyl‐Coenzyme A Analogue

Author(s) -

Spiteller Dieter,

Waterman Claire L.,

Spencer Jonathan B.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501670

Subject(s) - polyketide , polyketide synthase , biosynthesis , chemistry , coenzyme a , stereochemistry , malonyl coa , enzyme , cofactor , biochemistry , reductase , beta oxidation

Trapped in the middle : To investigate the mechanistic details of polyketide biosynthesis, intermediates are trapped by a nonhydrolyzable malonyl‐coenzyme A analogue that reacts with a growing polyketide chain formed by a stilbene synthase. As the reverse transesterification reaction is not possible, the polyketide intermediates accumulate attached to the analogue (see scheme; Enz=enzyme, CoA=coenzyme A).

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