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Solid/Solution‐Phase Annulation Reagents: Single‐Step Synthesis of Cyclic Amine Derivatives
Author(s) -
Dolle Roland E.,
MacLeod Calum,
MartinezTeipel Blanca,
Barker William,
Seida Pamela R.,
Herbertz Torsten
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501665
Subject(s) - reagent , amine gas treating , annulation , combinatorial chemistry , chemistry , cyclic amines , solid phase synthesis , organic chemistry , catalysis , biochemistry , peptide
Spanning the diversity gap: The conversion of primary amines into cyclic derivatives is achieved by using a family of amine‐derivatizing reagents, termed SPAn reagents (see scheme). The reagents, which require no further chemical manipulation or activation, are used to prepare discrete compounds or a library collection of diverse heterocycles. SPAn reagents have application in finding new lead compounds and the development of structure–activity relationships.