z-logo
Premium
Solid/Solution‐Phase Annulation Reagents: Single‐Step Synthesis of Cyclic Amine Derivatives
Author(s) -
Dolle Roland E.,
MacLeod Calum,
MartinezTeipel Blanca,
Barker William,
Seida Pamela R.,
Herbertz Torsten
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501665
Subject(s) - reagent , amine gas treating , annulation , combinatorial chemistry , chemistry , cyclic amines , solid phase synthesis , organic chemistry , catalysis , biochemistry , peptide
Spanning the diversity gap: The conversion of primary amines into cyclic derivatives is achieved by using a family of amine‐derivatizing reagents, termed SPAn reagents (see scheme). The reagents, which require no further chemical manipulation or activation, are used to prepare discrete compounds or a library collection of diverse heterocycles. SPAn reagents have application in finding new lead compounds and the development of structure–activity relationships.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here