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Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes
Author(s) -
Wu Wei,
Wieckowski Sébastien,
Pastorin Giorgia,
Benincasa Monica,
Klumpp Cédric,
Briand JeanPaul,
Gennaro Renato,
Prato Maurizio,
Bianco Alberto
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501613
Subject(s) - amphotericin b , fluorescein isothiocyanate , antifungal , carbon nanotube , isothiocyanate , drug delivery , nanotechnology , antifungal drug , fluorescein , chemistry , materials science , biochemistry , microbiology and biotechnology , fluorescence , biology , physics , quantum mechanics
Tasty tubes : Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB.