Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes | Zendy

Wu Wei | Zendy; Wieckowski Sébastien | Zendy; Pastorin Giorgia | Zendy; Benincasa Monica | Zendy; Klumpp Cédric | Zendy; Briand JeanPaul | Zendy; Gennaro Renato | Zendy; Prato Maurizio | Zendy; Bianco Alberto | Zendy

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Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes

Author(s) -

Wu Wei,

Wieckowski Sébastien,

Pastorin Giorgia,

Benincasa Monica,

Klumpp Cédric,

Briand JeanPaul,

Gennaro Renato,

Prato Maurizio,

Bianco Alberto

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501613

Subject(s) - amphotericin b , fluorescein isothiocyanate , antifungal , carbon nanotube , isothiocyanate , drug delivery , nanotechnology , antifungal drug , fluorescein , chemistry , materials science , biochemistry , microbiology and biotechnology , fluorescence , biology , physics , quantum mechanics

Tasty tubes : Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB.

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