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Expeditious, Potentially Primordial, Aminoacylation of Nucleotides
Author(s) -
Biron JeanPhilippe,
Parkes Alastair L.,
Pascal Robert,
Sutherland John D.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501591
Subject(s) - aminoacylation , nucleotide , chemistry , phosphoric acid , phosphate , intramolecular force , transfer rna , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , rna , gene
In the beginning : Mixed carboxylic phosphoric anhydrides 3 , formed from 3′‐nucleotides 1 and amino acid N ‐carboxyanhydrides 2 , undergo competing rearrangement to 2′‐aminoacyl esters 4 and cyclization to 2′,3′‐cyclic phosphates 5 . The intramolecular aminoacyl transfer is faster than the cyclization despite the ease with which 2′,3′‐cyclic phosphates are formed through any other form of phosphate activation.