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Alkali‐Metal‐Mediated Zincation of Ferrocene: Synthesis, Structure, and Reactivity of a Lithium Tmp/Zincate Reagent
Author(s) -
Barley Helen R. L.,
Clegg William,
Dale Sophie H.,
Hevia Eva,
Honeyman Gordon W.,
Kennedy Alan R.,
Mulvey Robert E.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501560
Subject(s) - zincate , reagent , tetramethylethylenediamine , chemistry , lithium (medication) , metalation , zinc , ferrocene , reactivity (psychology) , alkali metal , inorganic chemistry , medicinal chemistry , polymer chemistry , organic chemistry , electrochemistry , electrode , medicine , alternative medicine , pathology , endocrinology
Deprotonative metalation of ferrocene by a lithium zincate reagent was carried out to form the neutral zinc complex [(Fc) 2 Zn(tmeda)] and the anionic zincate [Li(thf) 4 ][(Fc) 3 Zn] (see scheme; tmp=2,2,6,6‐tetramethylpiperidine, TMEDA= N , N , N ′, N ′‐tetramethylethylenediamine). A 1:1:1 mixture of TMEDA, Li(tmp), and n Bu 2 Zn is used to readily prepare the lithium zincate reagent [Li n Bu 2 Zn(tmp)(tmeda)] in situ.