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Straightforward Access to a Structurally Diverse Set of Oxacyclic Scaffolds through a Four‐Component Reaction
Author(s) -
Jiménez Oscar,
de la Rosa Guillermo,
Lavilla Rodolfo
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501548
Subject(s) - modular design , set (abstract data type) , component (thermodynamics) , computer science , simplicity , diversity (politics) , adduct , process (computing) , character (mathematics) , condensation , combinatorial chemistry , chemistry , programming language , organic chemistry , mathematics , sociology , philosophy , physics , geometry , epistemology , anthropology , thermodynamics
Just add CH 3 CN and stir! Four building blocks taken in a multicomponent reaction (MCR, see picture; Tf=trifluoromethanesulfonyl) afford a β‐aminoacetal adduct, which can be further diversified by post‐condensation reactions. The modular character of this approach, the simplicity of the building blocks used, and the structural diversity attained render this process attractive for combinatorial as well as target‐ and diversity‐oriented synthesis.