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Facile Disulfide Bond Cleavage in Gaseous Peptide and Protein Cations by Ultraviolet Photodissociation at 157 nm
Author(s) -
Fung Y. M. Eva,
Kjeldsen Frank,
Silivra Oleg A.,
Chan T. W. Dominic,
Zubarev Roman A.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501533
Subject(s) - photodissociation , chemistry , dissociation (chemistry) , ultraviolet , ion , electron capture dissociation , photochemistry , cleavage (geology) , bond cleavage , disulfide bond , electron , catalysis , materials science , organic chemistry , optoelectronics , biochemistry , fracture (geology) , composite material , physics , quantum mechanics , fourier transform ion cyclotron resonance
Overall charge unchanged : Disulfide bonds in gaseous polypeptide cations can be cleaved efficiently by ultraviolet photodissociation (UVPD) at 157 nm (see scheme). Unlike electron‐capture dissociation, UVPD cleaves SS bonds without overall charge reduction in the product ions. This cleavage is suggested to be a result of electronic excitation caused by the absorption of photons of 7.9 eV.