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Stimuli‐Responsive Controlled Drug Release from a Hollow Mesoporous Silica Sphere/Polyelectrolyte Multilayer Core–Shell Structure
Author(s) -
Zhu Yufang,
Shi Jianlin,
Shen Weihua,
Dong Xiaoping,
Feng Jingwei,
Ruan Meilin,
Li Yongsheng
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501500
Subject(s) - polyelectrolyte , mesoporous silica , shell (structure) , mesoporous material , materials science , core (optical fiber) , chemical engineering , chemistry , composite material , organic chemistry , polymer , engineering , catalysis
Keeping drugs under control : Hydrothermally stable, hollow mesoporous silica spheres have a high drug storage capacity, and polyelectrolyte multilayers coated on the spheres act as a switch for drug release which is controlled by the pH or ionic strength of the release medium. The picture shows the release of ibuprofen (IBU) from spheres with and without coatings of sodium polystyrene sulfonate (PSS) and poly(allylamine hydrochloride) (PAH).

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