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Ruthenium‐Catalyzed Oxidative Cyanation of Tertiary Amines with Hydrogen Peroxide and Sodium Cyanide
Author(s) -
Murahashi ShunIchi,
Komiya Naruyoshi,
Terai Hiroyuki
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501496
Subject(s) - cyanation , hydrogen peroxide , chemistry , ruthenium , catalysis , oxidative phosphorylation , cyanide , hydrogen cyanide , aryl , peroxide , sodium cyanide , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , alkyl
Versatile intermediates for the synthesis of N ‐aryl‐α‐amino acids and N , N ‐disubstituted 1,2‐diamines can now be synthesized with high efficiency by the ruthenium‐catalyzed oxidative cyanation of tertiary amines. The use of hydrogen peroxide as an oxidant in the presence of NaCN/AcOH or HCN provides the corresponding α‐aminonitriles (see reaction).