Ruthenium‐Catalyzed Oxidative Cyanation of Tertiary Amines with Hydrogen Peroxide and Sodium Cyanide | Zendy

Murahashi ShunIchi | Zendy; Komiya Naruyoshi | Zendy; Terai Hiroyuki | Zendy

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Ruthenium‐Catalyzed Oxidative Cyanation of Tertiary Amines with Hydrogen Peroxide and Sodium Cyanide

Author(s) -

Murahashi ShunIchi,

Komiya Naruyoshi,

Terai Hiroyuki

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501496

Subject(s) - cyanation , hydrogen peroxide , chemistry , ruthenium , catalysis , oxidative phosphorylation , cyanide , hydrogen cyanide , aryl , peroxide , sodium cyanide , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , alkyl

Versatile intermediates for the synthesis of N ‐aryl‐α‐amino acids and N , N ‐disubstituted 1,2‐diamines can now be synthesized with high efficiency by the ruthenium‐catalyzed oxidative cyanation of tertiary amines. The use of hydrogen peroxide as an oxidant in the presence of NaCN/AcOH or HCN provides the corresponding α‐aminonitriles (see reaction).

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