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1,2‐Chirality Transfer in the Synthesis of Cyclopropanes
Author(s) -
Wessig Pablo,
Mühling Olaf
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501481
Subject(s) - desymmetrization , chirality (physics) , alkyl , group (periodic table) , stereochemistry , chemistry , axial chirality , transfer (computing) , enantioselective synthesis , organic chemistry , catalysis , physics , computer science , chiral symmetry breaking , quantum mechanics , quark , nambu–jona lasinio model , parallel computing
Influential neighbors : 1,2‐Chirality transfer provides the basis for a novel asymmetric synthesis of cyclopropanes by irradiation of enantiomerically pure alkyl phenyl ketones bearing a leaving group X in the α position. The photochemically excited carbonyl group is able to distinguish between the diastereotopic positions γ and γ′ in terms of a desymmetrization. In some cases the configuration is influenced by the temperature.
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