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Highly Regio‐ and Enantioselective Asymmetric Hydroformylation of Olefins Mediated by 2,5‐Disubstituted Phospholane Ligands
Author(s) -
Axtell Alex T.,
Cobley Christopher J.,
Klosin Jerzy,
Whiteker Gregory T.,
ZanottiGerosa Antonio,
Abboud Khalil A.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501478
Subject(s) - enantioselective synthesis , hydroformylation , chemistry , organic chemistry , catalysis , rhodium
Off the shelf : The commercially available ligand ( R , R )‐1,2‐bis(2,5‐diphenylphospholano)ethane (( R , R )‐Ph‐bpe) has been identified as an excellent ligand for asymmetric hydroformylation. State‐of‐the‐art regio‐ and enantioselectivities are obtained for reactions with styrene, allyl cyanide, and vinyl acetate as substrates while high reaction rates (>4000 turnovers h −1 ) are maintained (see scheme; Ac=acetate, b/l=branched/linear).