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Targeting Nucleic Acid Secondary Structures with Polyamides Using an Optimized Dynamic Combinatorial Approach
Author(s) -
Ladame Sylvain,
Whitney Andrew M.,
Balasubramanian Shankar
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501450
Subject(s) - nucleic acid , dna , polyamide , duplex (building) , chemistry , combinatorial chemistry , nucleic acid secondary structure , dna nanotechnology , g quadruplex , protein secondary structure , nucleic acid structure , peptide nucleic acid , selectivity , biophysics , biochemistry , rna , polymer chemistry , biology , gene , catalysis
Reversible disulfide chemistry is used to identify ligands that stabilize either duplex or quadruplex DNA secondary structures from a dynamic combinatorial library of polyamide building blocks (example structure shown). Double‐stranded DNA induces a larger amplification than quadruplex DNA, in accordance with the selectivity of the ligands for each DNA target.