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Catalytic Asymmetric Couplings of Ketenes with Aldehydes To Generate Enol Esters
Author(s) -
Schaefer Carsten,
Fu Gregory C.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501434
Subject(s) - enol , catalysis , chemistry , organic chemistry , coupling (piping) , carboxylic acid , combinatorial chemistry , materials science , metallurgy
With a little help from the ferrocenyl catalyst ((−)‐ 1 ), a wide array of α‐arylalkanoic acid derivatives can be produced from the catalytic asymmetric coupling of ketenes with aldehydes (see scheme). The enol esters are readily transformed into other useful families of compounds such as carboxylic acids and alcohols.