Titanium‐Catalyzed Intermolecular Hydroamination of Vinylarenes | Zendy

Kaspar Ludwig T. | Zendy; Fingerhut Benjamin | Zendy; Ackermann Lutz | Zendy

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Titanium‐Catalyzed Intermolecular Hydroamination of Vinylarenes

Author(s) -

Kaspar Ludwig T.,

Fingerhut Benjamin,

Ackermann Lutz

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501423

Subject(s) - hydroamination , intermolecular force , catalysis , chemistry , titanium , lewis acids and bases , derivative (finance) , alkylation , tetrahydroisoquinoline , organic chemistry , combinatorial chemistry , molecule , financial economics , economics

The Lewis acid TiCl 4 allows the intermolecular hydroamination of vinylarenes (see scheme). Some of the hydroamination products undergo rearrangements to give ortho ‐alkylated compounds. The catalyst tolerates a range of functional groups (R′=CF 3 , Cl, CN, F, Br) and provides the products in good yields. This method was also applied to the synthesis of a tetrahydroisoquinoline derivative.

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