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Label‐Free Detection of Protein–Protein Interactions on Biochips
Author(s) -
Yeo WoonSeok,
Min DalHee,
Hsieh Robert W.,
Greene Geoffrey L.,
Mrksich Milan
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501363
Subject(s) - biochip , chemistry , computational biology , nanotechnology , biology , materials science
Eliminating the middle‐man : The combination of MALDI‐TOF mass spectrometry and self‐assembled monolayers on gold (SAMDI) offers a new detection method for protein–ligand (shown) and protein–protein interactions. Proteins and protein complexes are selectively bound to biochips and then directly analyzed by MALDI‐TOF MS without the need for labels.