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Enantioselective Hydrogenation of Allylphthalimides: An Efficient Method for the Synthesis of β‐Methyl Chiral Amines
Author(s) -
Wang ChunJiang,
Sun Xianfeng,
Zhang Xumu
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501332
Subject(s) - enantioselective synthesis , asymmetric hydrogenation , catalysis , chemistry , hydrolysis , combinatorial chemistry , organic chemistry
High yields and up to 98 % ee have been achieved by asymmetric hydrogenation of allylphthalimides followed by hydrolysis to give β‐methyl chiral amines by using a Ru–C 3 ‐tunephos catalyst (see scheme). The synthetic utility of this procedure has been demonstrated through the synthesis of the key intermediate of the LTs receptor antagonist (Zeneca ZD 3532).