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Chiral Phosphine–Olefin Bidentate Ligands in Asymmetric Catalysis: Rhodium‐Catalyzed Asymmetric 1,4‐Addition of Aryl Boronic Acids to Maleimides
Author(s) -
Shintani Ryo,
Duan WeiLiang,
Nagano Takashi,
Okada Atsushi,
Hayashi Tamio
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501305
Subject(s) - phosphine , rhodium , denticity , olefin fiber , aryl , chemistry , catalysis , enantioselective synthesis , combinatorial chemistry , organic chemistry , asymmetric hydrogenation , crystal structure , alkyl
Two is better than one : Novel chiral phosphine–olefin ligands 1 a and 1 b act as bidentate ligands with some transition metals and have proved to be highly effective in the rhodium‐catalyzed asymmetric 1,4‐addition of aryl boronic acids to maleimides with high enantioselectivity (see scheme).