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Measuring Biomolecular Binding Events with a Compact Disc Player Device
Author(s) -
Lange Sebastian A.,
Roth Günter,
Wittemann Silke,
Lacoste Thilo,
Vetter Andreas,
Grässle Jürgen,
Kopta Susanne,
Kolleck Matthias,
Breitinger Beate,
Wick Manfred,
Hörber J. K. Heinrich,
Dübel Stefan,
Bernard André
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501243
Subject(s) - compact disc , computer science , physics , optics
Read the fine print : Biomolecular binding events can be counted with a readout system based on compact disc (CD) pickup technology. An immunoassay of C‐reactive protein was performed by microcontact printing of antibodies onto a support, autometallography, and imaging by a CD reader mounted on an optical microscope (see picture). The dynamic range was four orders of magnitude with a detection limit of 1 p M .