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A DNA–Protein Nanoengine for “On‐Demand” Release and Precise Delivery of Molecules
Author(s) -
Nutiu Razvan,
Li Yingfu
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501214
Subject(s) - dna , delivery system , enzyme , computer science , chemistry , computational biology , biochemistry , biology , pharmacology
A DNA aptamer (green in the scheme), an antisense DNA strand (purple), and an enzyme (blue) form a nanoengine that responds to a small‐molecule input (red) and dispatches a DNA output. The addition of the input promotes the first stroke of the nanoengine, the action of the enzyme the second stroke. Joint exploration of all components could lead to bionanodevices that can detect a biological malfunction and initiate a repair.
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