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Organocopper for the Craftsman Cunning at His Trade
Author(s) -
Woodward Simon
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501204
Subject(s) - allylic rearrangement , sn2 reaction , enantioselective synthesis , halide , conjugate , chemistry , copper , reagent , ligand (biochemistry) , catalysis , combinatorial chemistry , organic chemistry , mathematics , receptor , mathematical analysis , biochemistry
The organocopper craftsman's toolset is nearly complete with recent advances in ligand‐based catalytic organocopper chemistry, which make viable enantioselective 1,4‐conjugate additions and S N 2′ substitutions of allylic halides using Grignard, RZnCl, and organoaluminum reagents (see scheme) at low loadings of copper( I ) salts.
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