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Chiral Boron‐Bridged Bisoxazolines: Readily Available Anionic Ligands for Asymmetric Catalysis
Author(s) -
Mazet Clément,
Köhler Valentin,
Pfaltz Andreas
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501111
Subject(s) - chemistry , enantioselective synthesis , catalysis , stereochemistry , ligand (biochemistry) , electrophile , metal , oxazoline , chiral ligand , crystallography , organic chemistry , biochemistry , receptor
Asymmetric cyclopropanation and monobenzoylation reactions of meso diols employing borabox catalysts 1 (M=Cu) result in high enantioselectivities. The borabox ligands are anionic analogues of the bisoxazolines 2 and are readily prepared by lithiation of oxazolines and subsequent trapping with boron halides. The considerable potential of borabox ligands in asymmetric catalysis is shown.