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The Impact of Bacterial Genomics on Natural Product Research
Author(s) -
Bode Helge B.,
Müller Rolf
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501080
Subject(s) - natural product , natural product research , natural (archaeology) , biochemical engineering , genomics , computational biology , product (mathematics) , lead (geology) , microbiology and biotechnology , data science , biology , computer science , engineering , genome , genetics , biochemistry , mathematics , pharmacognosy , paleontology , geometry , gene , biological activity , in vitro
“There's life in the old dog yet!” This adage also holds true for natural product research. After the era of natural products was declared to be over, because of the introduction of combinatorial synthesis techniques, natural product research has taken a surprising turn back towards a major field of pharmaceutical research. Current challenges, such as emerging multidrug‐resistant bacteria, might be overcome by developments which combine genomic knowledge with applied biology and chemistry to identify, produce, and alter the structure of new lead compounds. Significant biological activity is reported much less frequently for synthetic compounds, a fact reflected in the large proportion of natural products and their derivatives in clinical use. This Review describes the impact of microbial genomics on natural products research, in particularly the search for new lead structures and their optimization. The limitations of this research are also discussed, thus allowing a look into future developments.