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A Gold Catalyst for Carbene‐Transfer Reactions from Ethyl Diazoacetate
Author(s) -
Fructos Manuel R.,
Belderrain Tomás R.,
de Frémont Pierre,
Scott Natalie M.,
Nolan Steven P.,
DíazRequejo M. Mar,
Pérez Pedro J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501056
Subject(s) - carbene , ethyl diazoacetate , styrene , toluene , catalysis , benzene , chemistry , medicinal chemistry , organic chemistry , polymer chemistry , cyclopropanation , copolymer , polymer
Approaching El Dorado : A gold catalyst has been discovered that transfers a carbene unit from ethyl diazoacetate to aromatic substrates (see scheme) as well as olefins, amines, and alcohols. The insertion of carbene units into the CH bonds of the aromatic ring of benzene, toluene, and styrene is a novel reaction. R=H, CH 3 , CHCH 2 ; IPr=1,3‐bis(diisopropylphenyl)imidazol‐2‐ylidene.