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Synthesis of an Optically Active C 1 ‐Symmetric Al(salalen) Complex and Its Application to the Catalytic Hydrophosphonylation of Aldehydes
Author(s) -
Saito Bunnai,
Katsuki Tsutomu
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501008
Subject(s) - catalysis , enantioselective synthesis , chemistry , optically active , trigonal bipyramidal molecular geometry , organic chemistry , scheme (mathematics) , aldehyde , combinatorial chemistry , medicinal chemistry , molecule , mathematics , mathematical analysis
Quite universally : The chiral trigonal‐bipyramidal Al(salalen) complex 1 was synthesized and found to be an efficient catalyst for enantioselective hydrophosphonylation of various aldehydes with dimethyl phosphite (see scheme). This is the first example where a molecular catalyst can be applied to the reactions of both aromatic and aliphatic aldehydes with enantioselectivities greater than 80 % ee.