Synthesis of an Optically Active  C  1 ‐Symmetric Al(salalen) Complex and Its Application to the Catalytic Hydrophosphonylation of Aldehydes | Zendy

Saito Bunnai | Zendy; Katsuki Tsutomu | Zendy

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Synthesis of an Optically Active C 1 ‐Symmetric Al(salalen) Complex and Its Application to the Catalytic Hydrophosphonylation of Aldehydes

Author(s) -

Saito Bunnai,

Katsuki Tsutomu

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200501008

Subject(s) - catalysis , enantioselective synthesis , chemistry , optically active , trigonal bipyramidal molecular geometry , organic chemistry , scheme (mathematics) , aldehyde , combinatorial chemistry , medicinal chemistry , molecule , mathematics , mathematical analysis

Quite universally : The chiral trigonal‐bipyramidal Al(salalen) complex 1 was synthesized and found to be an efficient catalyst for enantioselective hydrophosphonylation of various aldehydes with dimethyl phosphite (see scheme). This is the first example where a molecular catalyst can be applied to the reactions of both aromatic and aliphatic aldehydes with enantioselectivities greater than 80 % ee.

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