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Oxidation of Guanine and 8‐oxo‐7,8‐Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen‐18 Labeling Experiments
Author(s) -
Crean Conor,
Geacintov Nicholas E.,
Shafirovich Vladimir
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500991
Subject(s) - guanine , chemistry , radical , nucleobase , carbonate , oxygen , photochemistry , ion , dna damage , dna oxidation , oxidative phosphorylation , dna , biochemistry , organic chemistry , nucleotide , gene
Under oxidative stress : The oxidation of guanine and 8‐oxo‐7,8‐dihydroguanine has been monitored by 18 O‐labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O − from CO 3 .− to the end products (see scheme).
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