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Couplings with Monoorganotin Compounds: A “Radical” Twist from the Original Stille Reaction
Author(s) -
Echavarren Antonio M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500918
Subject(s) - stille reaction , halide , alkyl , twist , nickel , chemistry , scheme (mathematics) , combinatorial chemistry , computational chemistry , organic chemistry , catalysis , mathematics , mathematical analysis , geometry
Revamped for the 21st century : The original Stille protocols for cross‐couplings are difficult to recognize in the newer nickel‐catalyzed reactions of monoorganotin compounds with secondary alkyl halides (see scheme). This new coupling scheme avoids the formation of toxic byproducts.