Nucleic Acid with Guanidinium Modification Exhibits Efficient Cellular Uptake | Zendy

Ohmichi Tatsuo | Zendy; Kuwahara Masayasu | Zendy; Sasaki Naoko | Zendy; Hasegawa Masatoshi | Zendy; Nishikata Takahito | Zendy; Sawai Hiroaki | Zendy; Sugimoto Naoki | Zendy

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Nucleic Acid with Guanidinium Modification Exhibits Efficient Cellular Uptake

Author(s) -

Ohmichi Tatsuo,

Kuwahara Masayasu,

Sasaki Naoko,

Hasegawa Masatoshi,

Nishikata Takahito,

Sawai Hiroaki,

Sugimoto Naoki

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500904

Subject(s) - oligomer , hela , nucleic acid , dna , fluorescence , fluorescence microscope , deoxyuridine , chemistry , biophysics , biochemistry , microbiology and biotechnology , combinatorial chemistry , computational biology , biology , organic chemistry , cell , physics , quantum mechanics

Quick on the uptake : A 20‐mer DNA oligomer modified with 5‐[(6‐guanidiniohexylcarbamoyl)methyl]‐2′‐deoxyuridine ( Tg ) shows efficient cellular uptake (blue arrow) in HeLa cells without any other reagents. The fluorescence microscopy image reveals FAM‐labeled DNA oligomer (green) and stained nuclei (blue). FAM=6‐carboxyfluorescein.

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