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Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative
Author(s) -
Zhao Fang,
Zhao Qiang,
Blount Kenneth F.,
Han Qing,
Tor Yitzhak,
Hermann Thomas
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500903
Subject(s) - neomycin , aminoglycoside , antibiotics , rna , chemistry , derivative (finance) , stereochemistry , natural product , intramolecular force , biochemistry , gene , financial economics , economics
The preorganized presentation of functional groups in the antibiotic neomycin (green) is exploited to obtain a conformationally restricted aminoglycoside (yellow) by regioselective intramolecular cyclization. X‐ray crystallography data show how the natural product and the derivative recognize the RNA target motif that is the binding site of aminoglycoside antibiotics.