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In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers
Author(s) -
Nesterov Evgueni E.,
Skoch Jesse,
Hyman Bradley T.,
Klunk William E.,
Bacskai Brian J.,
Swager Timothy M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500845
Subject(s) - in vivo , amyloid (mycology) , optical imaging , amyloid β , neuroscience , biomarker , rational design , brain tissue , fluorescence , computer science , neuroimaging , pathology , chemistry , medicine , disease , nanotechnology , biology , biochemistry , materials science , microbiology and biotechnology , optics , physics
Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid‐β plaques in the brain. A rational design strategy for in vivo amyloid‐imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported.