In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers | Zendy

Nesterov Evgueni E. | Zendy; Skoch Jesse | Zendy; Hyman Bradley T. | Zendy; Klunk William E. | Zendy; Bacskai Brian J. | Zendy; Swager Timothy M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

Author(s) -

Nesterov Evgueni E.,

Skoch Jesse,

Hyman Bradley T.,

Klunk William E.,

Bacskai Brian J.,

Swager Timothy M.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500845

Subject(s) - in vivo , amyloid (mycology) , optical imaging , amyloid β , neuroscience , biomarker , rational design , brain tissue , fluorescence , computer science , neuroimaging , pathology , chemistry , medicine , disease , nanotechnology , biology , biochemistry , materials science , microbiology and biotechnology , optics , physics

Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid‐β plaques in the brain. A rational design strategy for in vivo amyloid‐imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research