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Prodrug Activation Gated by a Molecular “OR” Logic Trigger
Author(s) -
Amir Roey J.,
Popkov Mikhail,
Lerner Richard A.,
Barbas Carlos F.,
Shabat Doron
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500842
Subject(s) - prodrug , linker , masking (illustration) , computer science , chemistry , logic gate , combinatorial chemistry , biochemistry , algorithm , programming language , art , visual arts
Molecules that define logic : A molecular “OR” logic gate trigger has been demonstrated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).
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