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Direct Synthesis of a Thiolato‐S and Sulfinato‐S Co III Complex Related to the Active Site of Nitrile Hydratase: A Pathway to the Post‐Translational Oxidation of the Protein
Author(s) -
Bourles Emilie,
Alves de Sousa Rodolphe,
Galardon Erwan,
Giorgi Michel,
Artaud Isabelle
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500814
Subject(s) - nitrile , nitrile hydratase , chemistry , metalation , hydrolysis , active site , cleavage (geology) , stereochemistry , combinatorial chemistry , enzyme , biochemistry , organic chemistry , biology , paleontology , fracture (geology)
Cyclic pseudopeptidic thiosulfinates reveal a new type of reaction that may be important in biological systems. It involves hydrolytic cleavage of the S(O)S bond on 1 followed by metalation to form a dissymmetrical Co III complex with a mixed diamidato‐N, thiolato‐S, sulfinato‐S donor set in 2 that is related to the nitrile hydratase active site.