Direct Synthesis of a Thiolato‐S and Sulfinato‐S Co III  Complex Related to the Active Site of Nitrile Hydratase: A Pathway to the Post‐Translational Oxidation of the Protein | Zendy

Bourles Emilie | Zendy; Alves de Sousa Rodolphe | Zendy; Galardon Erwan | Zendy; Giorgi Michel | Zendy; Artaud Isabelle | Zendy

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Direct Synthesis of a Thiolato‐S and Sulfinato‐S Co III Complex Related to the Active Site of Nitrile Hydratase: A Pathway to the Post‐Translational Oxidation of the Protein

Author(s) -

Bourles Emilie,

Alves de Sousa Rodolphe,

Galardon Erwan,

Giorgi Michel,

Artaud Isabelle

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500814

Subject(s) - nitrile , nitrile hydratase , chemistry , metalation , hydrolysis , active site , cleavage (geology) , stereochemistry , combinatorial chemistry , enzyme , biochemistry , organic chemistry , biology , paleontology , fracture (geology)

Cyclic pseudopeptidic thiosulfinates reveal a new type of reaction that may be important in biological systems. It involves hydrolytic cleavage of the S(O)S bond on 1 followed by metalation to form a dissymmetrical Co III complex with a mixed diamidato‐N, thiolato‐S, sulfinato‐S donor set in 2 that is related to the nitrile hydratase active site.

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