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Molecular‐Weight‐Tagged Glycopeptide Library: Efficient Construction and Applications
Author(s) -
Ito Hiromi,
Kameyama Akihiko,
Sato Takashi,
Kiyohara Katsue,
Nakahara Yoshiaki,
Narimatsu Hisashi
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500802
Subject(s) - glycopeptide , glycosyl , component (thermodynamics) , oligosaccharide , chemistry , mass spectrometry , combinatorial chemistry , computer science , stereochemistry , biochemistry , chromatography , physics , thermodynamics , antibiotics
Generation of diversity : An oligosaccharide library can be constructed from glycopeptides by repeating incomplete glycosyltransferse (GTs) reactions in a single tube (see picture). Each product has a different molecular weight (MW). Therefore, the structure of each component in the library can be identified immediately by mass spectrometry alone. The differently colored shapes in the picture symbolize different glycosyl residues.