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Synthesis of Seven‐Membered‐Ring Ketones by Arylative Ring Expansion of Alkyne‐Substituted Cyclobutanones
Author(s) -
Matsuda Takanori,
Makino Masaomi,
Murakami Masahiro
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500799
Subject(s) - rhodium , chemistry , alkyne , intramolecular force , ring (chemistry) , annulation , aryl , moiety , catalysis , bicyclic molecule , stereochemistry , ring strain , hydroacylation , medicinal chemistry , organic chemistry , alkyl
Ever‐increasing circles : Seven‐membered‐ring ketones are constructed by a rhodium( I )‐catalyzed arylative ring‐expansion reaction of alkyne‐substituted aryl cyclobutanones, in which two CC bond‐forming and one CC bond‐cleaving events occur consecutively (see scheme).