A Catalytic Asymmetric Three‐Component 1,4‐Addition/Aldol Reaction: Enantioselective Synthesis of the Spirocyclic System of Vannusal A | Zendy

Nicolaou K. C. | Zendy; Tang Wenjun | Zendy; Dagneau Philippe | Zendy; Faraoni Raffaella | Zendy

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A Catalytic Asymmetric Three‐Component 1,4‐Addition/Aldol Reaction: Enantioselective Synthesis of the Spirocyclic System of Vannusal A

Author(s) -

Nicolaou K. C.,

Tang Wenjun,

Dagneau Philippe,

Faraoni Raffaella

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500789

Subject(s) - enantioselective synthesis , aldol reaction , catalysis , component (thermodynamics) , zirconium , chemistry , organic chemistry , medicinal chemistry , stereochemistry , physics , thermodynamics

Three's not always a crowd : A three‐component reaction involving α,β‐unsaturated enones 1 , aldehydes 2 , and alkenyl zirconium species 3 in the presence of a Rh–binap catalyst leads, sequentially, to aldols 4 , enones 5 , and 2,3‐disubstituted cycloalkanones 6 in good yields and with high ee values.

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