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Divergent Synthesis of Sialylated Glycan Chains: Combined Use of Polymer Support, Resin Capture–Release, and Chemoenzymatic Strategies
Author(s) -
Hanashima Shinya,
Manabe Shino,
Ito Yukishige
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500777
Subject(s) - glycan , glycosylation , chemistry , polymer , polysaccharide , biochemistry , combinatorial chemistry , polymer chemistry , organic chemistry , glycoprotein
Carbo loading! The synthesis of α(2,3)‐ or α(2,6)‐sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture–release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn=benzyl, TBS= tert ‐butyldimethylsilyl.