Divergent Synthesis of Sialylated Glycan Chains: Combined Use of Polymer Support, Resin Capture–Release, and Chemoenzymatic Strategies | Zendy

Hanashima Shinya | Zendy; Manabe Shino | Zendy; Ito Yukishige | Zendy

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Divergent Synthesis of Sialylated Glycan Chains: Combined Use of Polymer Support, Resin Capture–Release, and Chemoenzymatic Strategies

Author(s) -

Hanashima Shinya,

Manabe Shino,

Ito Yukishige

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500777

Subject(s) - glycan , glycosylation , chemistry , polymer , polysaccharide , biochemistry , combinatorial chemistry , polymer chemistry , organic chemistry , glycoprotein

Carbo loading! The synthesis of α(2,3)‐ or α(2,6)‐sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture–release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn=benzyl, TBS= tert ‐butyldimethylsilyl.

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